LONDON: Novavax Inc. said Thursday that its COVID-19 vaccine appears 89% effective based on early findings from a British study and that it also seems to work — though not as well — against new mutated versions of the virus circulating in that country and South Africa.
The announcement comes amid worry about whether a variety of vaccines being rolled out around the world will be strong enough to protect against worrisome new variants – and as the world desperately needs new types of shots to boost scarce supplies.
The study of 15,000 people in Britain is still underway. But an interim analysis found 62 participants so far have been diagnosed with COVID-19 – only six of them in the group that got vaccine and the rest who received dummy shots.
The infections occurred at a time when Britain was experiencing a jump in COVID-19 caused by a more contagious variant. A preliminary analysis found over half of the trial participants who became infected had the mutated version. The numbers are very small, but Novavax said they suggest the vaccine is nearly 96% effective against the older coronavirus and nearly 86% effective against the new variant. The findings are based on cases that occurred at least a week after the second dose.
“Both those numbers are dramatic demonstrations of the ability of our vaccine to develop a very potent immune response,” Novavax CEO Stanley Erck said in a call with investors late Thursday.
Scientists have been even more worried about a variant first discovered in South Africa that carries different mutations. Results from a smaller Novavax study in that country suggests the vaccine does work but not nearly as well as it does against the variant from Britain.
The South African study included some volunteers with HIV. Among the HIV-negative volunteers, the vaccine appears 60% effective. Including volunteers with HIV, overall the protection was 49%, the company said. While genetic testing still is underway, so far about 90% of the COVID-19 illnesses found in the South African study appear due to the new mutant.
“These are good results. There is reason to be optimistic” about the 60% effectiveness, said Glenda Gray, head of the South African Medical Research Council. Even against the new variant that now causes more than 90% of new cases in that country, “we’re still seeing vaccine efficacy,” she said.
More concerning is what the study showed about a totally different question — the chances of people getting COVID-19 a second time, said the leader of the South African study, Shabir Madhi of the University of the Witwatersrand in Johannesburg. Tests suggested that nearly a third of study participants had been previously infected, yet rates of new infections in the placebo group were similar.
“Past infection with early variants of the virus in South Africa does not protect” against infection with the new one, he said. “There doesn’t seem to be any protection derived.”
Novavax said it needs some additional data before it can seek British authorization for the vaccine’s use, sometime in the next month or so. A larger study in the US and Mexico has enrolled slightly over half of the needed 30,000 volunteers. Novavax said it’s not clear if the Food and Drug Administration will need data from that study, too, before deciding whether to allow US use.
Meanwhile, it is starting to develop a version of the vaccine that could more specifically target the mutations found in South Africa, in case health authorities eventually decide that updated dosing is needed.
Vaccines against COVID-19 train the body to recognize the new coronavirus, mostly the spike protein that coats it. But the Novavax candidate is made differently than the first shots being used. Called a recombinant protein vaccine, the Maryland company uses genetic engineering to grow harmless copies of the coronavirus spike protein in insect cells. Scientists extract and purify the protein and then mix in an immune-boosting chemical.
Novavax COVID-19 vaccine works, but less so against variants
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Novavax COVID-19 vaccine works, but less so against variants
- Novavax said the figures suggest their vaccine is nearly 96% effective against the older coronavirus and 86% against the new variant
Suspected Kashmir rebels kill Indian air force corporal
- Suspected rebels ambushed military convoy in Indian-administered Kashmir, Indian Air Force says
- Since 1989, rebel groups opposed to Indian rule have waged insurgency in disputed territory
SRINAGAR, India: An Indian air force member was killed and four more injured when suspected rebels ambushed a military convoy in Indian-administered Kashmir, an official statement said, as campaigning for national elections continues in the disputed territory.
The convoy was attacked by an unknown number of armed militants who sprayed automatic rifle fire toward at least one air force truck in the mountainous Poonch area, 200 kilometers (124 miles) south of the main city of Srinagar, the air force said in a statement.
Five air force personnel were hit in the firefight late Saturday and “one Air Warrior succumbed to his injuries later,” it said, identifying the dead man as a corporal.
A neighboring constituency took part in the first phase of India’s general election on April 19, and Poonch voters were originally scheduled to cast their ballots this week but the Election Commission of India has postponed the polling to May 25 because of inclement weather in recent days.
Kashmir has been divided between India and Pakistan since their independence in 1947, with both claiming the high-altitude territory in full but administering it in parts.
Since 1989, rebel groups opposed to Indian rule have waged an insurgency in Indian-controlled Kashmir, demanding either independence or a merger with Pakistan.
The conflict has left tens of thousands of civilians, soldiers and militants dead.
Rebel activity in the territory has registered an uptick since last month as campaigning for the elections picked up in the restive region.
In April, three suspected rebels were killed and a police officer and three soldiers wounded in three separate clashes across the territory.
Violence has drastically dropped since 2019, when Prime Minister Narendra Modi’s government revoked the region’s limited autonomy and stepped up a security chokehold.
Voting in India’s six-week-long national election, which started last month, will end on June 1.
Driver dies after crashing into White House perimeter gate, Secret Service says
- The driver was not immediately identified
WASHINGTON: A driver died after crashing a vehicle into a gate at the White House Saturday night, authorities said.
The driver was found dead in the vehicle following the crash shortly before 10:30 p.m. at an outer perimeter gate of the White House complex, the US Secret Service said in a statement.
Security protocols were implemented but there was no threat to the White House, the agency said.
The driver was not immediately identified.
The Secret Service will continue to investigate the matter, while turning over the fatal crash portion of the investigation to the Washington Metropolitan Police Department, the agency said.
Fake videos of Modi aides trigger political showdown in India election
- Indian police arrest nine people for circulating fake video of Indian Home Minister Amit Shah
- With more than 800 million Internet users, tackling misinformation in India is a huge challenge
BENGALURU/LUCKNOW: Manipulated videos are taking center stage as campaigning heats up in India’s election, with fake clips involving two top aides of Prime Minister Narendra Modi triggering police investigations and the arrest of some workers of his rival Congress party.
In what has been dubbed as India’s first AI election, Modi said last week fake voices were being used to purportedly show leaders making “statements that we have never even thought of,” calling it a conspiracy “to create tension in society.”
Indian police — already investigating the spread of fake videos showing Bollywood actors criticizing Modi — are now investigating a doctored online clip that showed federal home minister Amit Shah saying the ruling Bharatiya Janata Party will stop certain social guarantees for minorities, a subject sensitive for millions of voters.
Shah retorted on X, posting his “original” and the edited “fake” speech and alleging — without providing any evidence — that the main opposition Congress was behind the video it created to mislead the public. The minister said “directions have been issued to the police to address this issue.”
Indian police arrested at least nine people, including six members of Congress’ social media teams, in the states of Assam, Gujarat, Telangana and New Delhi last week for circulating the fake video, according to police statements.
Five of the Congress workers were released on bail, but the most high-profile arrest made by the cybercrime unit of New Delhi police came on Friday, when they detained a Congress national social media coordinator, Arun Reddy, for sharing the video. New Delhi is one region where Shah’s ministry directly controls police. Reddy has been sent into three-day custody.
The arrest has sparked protests from Congress workers with many posting on X using the #ReleaseArunReddy tag. Congress lawmaker Manickam Tagore said the arrest was an example of “authoritarian misuse of power by the regime.”
Congress’ head of social media, Supriya Shrinate, did not respond to messages and an email seeking comment.
MISINFORMATION
India’s election from April 19 to June 1 will be the world’s largest democratic event. With nearly a billion voters and more than 800 million Internet users, tackling the spread of misinformation is a high stakes job. It involves round-the-clock monitoring by police and election officials who often issue take down orders to Facebook and X as investigations start.
In India’s most populous state of Uttar Pradesh, more than 500 people keep tabs on online content, flagging controversial posts and coordinating with social media companies for their removal when needed, police chief Prashant Kumar told Reuters on Saturday.
Another fake video that sparked a storm last week showed Yogi Adityanath, the state’s chief minister, criticizing Modi for not doing enough for families of those who died in a 2019 militant attack. Though fact checkers said the video was created using different parts of an original clip, state police called it an “AI generated, deepfake.”
Using Internet address tracking, state police arrested a man named Shyam Gupta on May 2 who had shared the fake video post on X a day earlier, receiving over 3,000 views and 11 likes.
The police have accused Gupta of forgery and promoting enmity under Indian law provisions that can carry a jail term of up to seven years if convicted. Reuters could not reach him as he is currently serving a 14-day custody period.
“This person is not a tech guy. Had he been tech savvy, arresting him quickly would not have been possible,” said police officer Kumar.
Australian police shoot boy dead after stabbing with ‘hallmarks’ of terrorism
SYDNEY,: Australian police said on Sunday they had shot dead a boy after he stabbed a man in Western Australia’s capital Perth, in an attack authorities said indicated terrorism.
There were signs the 16-year-old, armed with a kitchen knife, had been radicalized online, state authorities said, adding they received calls from concerned members of the local Muslim community before the attack, which occurred late on Saturday night.
The attack, in the suburb of Willetton, had “hallmarks” of terrorism but was yet to be declared a terrorist act, police said.
“At this stage it appears that he acted solely and alone,” Western Australia Premier Roger Cook told a televised press conference in the state capital Perth, regarding the attacker.
The victim, stabbed in the back, was stable in hospital, authorities said.
Prime Minister Anthony Albanese said he had been briefed on the incident by police and intelligence agencies, which advised there was no ongoing threat.
“We are a peace-loving nation and there is no place for violent extremism in Australia,” Albanese said on social media platform X.
The incident comes after New South Wales police last month charged several boys with terrorism-related offenses in investigations following the stabbing of an Assyrian Christian bishop while he was giving a live-streamed sermon in Sydney, on April 15.
The attack on the bishop came only days after a stabbing spree killed six in the Sydney beachside suburb of Bondi.
Gun and knife crime is rare in Australia, which consistently ranks among the safest countries in the world, according to the federal government. (Reporting by Sam McKeith in Sydney; Editing by Christian Schmollinger and William Mallard)
North Korea’s UN ambassador says new sanctions monitoring groups will fail
- Earlier this year, Russia vetoed the annual renewal of a panel of experts amid US-led accusations that North Korea has transferred weapons to Russia for use in its war in Ukraine
SEOUL: Efforts led by the US and other Western countries to form new groups to monitor sanctions on North Korea will fail, the country’s UN envoy said on Sunday, according to state media KCNA.
Ambassador Kim Song made the comment in response to a joint statement the US and its allies issued this week calling to continue the work of a UN panel of experts monitoring longstanding sanctions against Pyongyang for its nuclear weapons and missile programs.
Earlier this year, Russia vetoed the annual renewal of the panel amid US-led accusations that North Korea has transferred weapons to Russia for use in its war in Ukraine.
“The hostile forces may set up the second and third expert panels in the future but they are all bound to meet self-destruction with the passage of time,” KCNA quotes Kim as saying in a statement.
Last month, US Ambassador to the United Nations Linda Thomas-Greenfield visited the Demilitarized Zone, a heavily fortified border between the two Koreas, which remain technically at war and urged Russia and China to stop rewarding North Korea for its bad behavior.
Her trip came after Russia rejected the annual renewal of the multinational panel of experts that has over the past 15 years monitored the implementation of UN sanctions aimed at curbing North Korea’s nuclear and missile programs.
