Novartis drug cuts recurrence risk by 25% in early-stage breast cancer

Novartis breast cancer drug Kisqali cut the risk of recurrence by more than 25% in a pivotal trial on women diagnosed at an early stage. (AFP/File)
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Updated 03 June 2023
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Novartis drug cuts recurrence risk by 25% in early-stage breast cancer

  • The company on Friday said the relative risk reduction of cancer recurrence was 25.2%
  • The results were broadly consistent regardless of patients' menopausal status or cancer progression status

FRANKFURT: Novartis breast cancer drug Kisqali cut the risk of recurrence by more than 25 percent in a pivotal trial on women diagnosed at an early stage, positioning the Swiss drugmaker to win new patients and but facing strong competition from Eli Lilly.
The company on Friday said the relative risk reduction of cancer recurrence was 25.2 percent and that the results were broadly consistent regardless of patients’ menopausal status or cancer progression status. The results were presented at the annual meeting of the American Society of Clinical Oncology in Chicago.
The Swiss drugmaker’s shares rose, even as the efficacy read-out fell short of that of a drug by Lilly, but a more favorable side effect profile might swing the balance in favor of Kisqali.
The drug was used in the trial together with standard endocrine therapy to treat a type of cancer that grows in response to hormones and it was compared to endocrine therapy alone.
The Novartis treatment has been approved to treat hormone-driven breast cancer that has spread to other parts of the body, where Novartis has taken market share from Pfizer’s Ibrance.
But an earlier diagnosis, when tumors can still be surgically removed, is much more common, representing about 90 percent of patients.
Still, better drugs are needed after surgery because the cancer later returns in between a third and one half of cases.
Eli Lilly is ahead with the approval of rival drug Verzenio in the early setting. But that is in a subset of women who are at high risk of recurrence after surgery, typically diagnosed based on signs of cancer in the lymph nodes.
Here, Novartis will face tough competition because the US drugmaker has said Verzenio reduces the risk of recurrence by 35 percent in that group.
But Kisqali looks set to be a pioneer in a wider market because it was tested successfully in both high-risk and medium-risk patients, a population that is twice as large.
Analysts have said investors could be disappointed if the Kisqali read-out fell well short of Verzenio’s efficacy and Jefferies analysts said on Friday the efficacy read-out was “closer to our downside scenario.”
But Novartis stressed very low rates of symptomatic side effects in its trial, important to patients facing years-long treatment, with severe diarrhea affecting only 0.6 percent of participants on Kisqali.
That compares with 8 percent-20 percent of the women in trials with Eli Lilly’s Verzenio being affected by severe diarrhea.
“This may be very relevant commercially,” said Evercore ISI analyst Umer Raffat.
Novartis shares were up 1.5 percent at 1430 GMT, rebounding from initial losses after the news. Lilly shares gained 0.9 percent.
“We know diarrhea can be a very troublesome, burdensome adverse event for patients taking anti-cancer medicines,” said Jeff Legos, Head of Oncology & Hematology Development at Novartis.
The March trial update boosted market confidence in targets issued by CEO Vas Narasimhan for annual sales growth of 4 percent through 2027 and a core operating income margin of 40 percent from 2027, analysts have said.
Novartis will request approval for wider use in the US and Europe before the end of the year, it added.
Novartis gave a brief preview of the Kisqali data in March, boosting its shares and growth prospects.


California governor says ‘democracy is under assault’ by Trump as feds intervene in LA protests

Updated 3 sec ago
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California governor says ‘democracy is under assault’ by Trump as feds intervene in LA protests

  • Gavin Newsom: ‘California may be first, but it clearly will not end here. Other states are next’
  • California governor is head of the heavily Democratic state known as the epicenter of the so-called Trump resistance

LOS ANGELES: Calling President Donald Trump a threat to the American way of life, Governor Gavin Newsom depicted the federal military intervention in Los Angeles as the onset of a much broader effort by Trump to overturn political and cultural norms at the heart of the nation’s democracy.

In a speech Tuesday evening, the potential 2028 Democratic presidential candidate said the arrival of National Guard and Marine troops in the city at Trump’s direction was not simply about quelling protests that followed a series of immigration raids by federal authorities. Instead, he said, it was part of a calculated “war” intended to upend the foundations of society and concentrate power in the White House.

“California may be first, but it clearly will not end here. Other states are next,” a somber Newsom warned, seated before the US and California flags. “Democracy is next. Democracy is under assault before our eyes. This moment we have feared has arrived.”

As head of the heavily Democratic state known as the epicenter of the so-called Trump resistance, Newsom and the Republican president have long been adversaries. But the governor’s speech delivered in prime time argued that Trump was not just a threat to democracy, but was actively working to break down its guardrails that reach back to the nation’s founding.

″He’s declared a war. A war on culture, on history, on science, on knowledge itself,” Newsom said. “He’s delegitimizing news organizations, and he’s assaulting the First Amendment.”

Newsom added that Trump is attacking law firms and the judicial branch – “the foundations of an orderly and civil society.”

“It’s time for all of us to stand up,” Newsom said, urging any protests to be peaceful. “What Donald Trump wants most is your fealty, your silence, to be complicit in this moment. Do not give in to him.”

His speech came the same day that Newsom asked a court to put an emergency stop to the military helping federal immigration agents, with some guardsmen now standing in protective gauntlet around agents as they carried out arrests. The judge chose not to rule immediately, giving the Trump administration several days to continue those activities before a hearing Thursday.

Trump has activated more than 4,000 National Guard members and 700 Marines over the objections of city and state leaders, though the Marines have not yet been spotted in Los Angeles and Guard troops have had limited engagement with protesters. They were originally deployed to protect federal buildings.

Newsom’s speech capped several days of acidic exchanges between Trump and Newsom, that included the president appearing to endorse Newsom’s arrest if he interfered with federal immigration enforcement. “I think it’s great. Gavin likes the publicity, but I think it would be a great thing,” Trump told reporters.

Over the years, Trump has threatened to intercede in California’s long-running homeless crisis, vowed to withhold federal wildfire aid as political leverage in a dispute over water rights, called on police to shoot people robbing stores and warned residents that “your children are in danger” because of illegal immigration.

Trump relishes insulting the two-term governor and former San Francisco mayor – frequently referring to him as Gov. “New-scum” – and earlier this year faulted the governor for Southern California’s deadly wildfires.

Trump has argued that the city was in danger of being overrun by violent protesters, while Newsom and Los Angeles Mayor Karen Bass have called the federal intervention an unneeded – and potentially dangerous – overreaction.

The demonstrations have been mostly concentrated in the city’s downtown hub. Demonstrations have spread to other cities in the state and nationwide, including Dallas and Austin, Texas, Chicago and New York City, where a thousand people rallied and multiple arrests were made.

Trump left open the possibility of invoking the Insurrection Act, which authorizes the president to deploy military forces inside the US to suppress rebellion or domestic violence or to enforce the law in certain situations. It’s one of the most extreme emergency powers available to a US president.

“If there’s an insurrection, I would certainly invoke it. We’ll see,” he said from the Oval Office.


Ukraine says Russian strikes hit Kharkiv, killing two

Updated 8 min 11 sec ago
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Ukraine says Russian strikes hit Kharkiv, killing two

  • The State Emergency Service of Ukraine said eight children were wounded in the attack
  • Peace talks in Turkiye last week failed to yield a breakthrough toward ending the conflict

KYIV; killed two people and wounded 54 including children early Wednesday, authorities said, as Moscow pushed ahead with its relentless attacks after rejecting an unconditional ceasefire.

“Seventeen strikes by enemy UAVs (drones) were carried out in two districts of the city tonight,” Kharkiv Mayor Igor Terekhov said on Telegram, later adding that 37 people were wounded and “several people were rescued from houses engulfed in flames.”

The State Emergency Service of Ukraine said eight children were wounded in the attack.

Russia has escalated its bombardments of Ukraine despite US President Donald Trump urging Moscow to end its three-year invasion, with Kyiv launching retaliatory attacks deep inside Russian territory.

After a previous overnight barrage of more than 300 drones and seven missiles on Tuesday, Ukrainian President Volodymyr Zelensky urged Kyiv’s Western allies to respond with “concrete action.”

“Action from America, which has the power to force Russia into peace. Action from Europe, which has no alternative but to be strong,” Zelensky wrote on social media.

Peace talks in Turkiye last week failed to yield a breakthrough toward ending the conflict, with Russia rejecting calls for an unconditional ceasefire and demanding Ukraine give up its territory and bid to join NATO.

But the two sides agreed to swap more than 1,000 prisoners of war and hand over the bodies of dead soldiers, swapping groups of captured soldiers on Monday and Tuesday.

Kharkhiv, which lies less than 50 kilometers from the Russian border, has been hit by a surge in large-scale nighttime attacks over the past week.

Wednesday’s strikes left a five-story building on fire in Slobidskyi district, while several houses were hit in Osnovyansky district, Mayor Terekhov said.

He said “there may be people trapped under the rubble.”

The attack came after Russia pummelled the city on Saturday in what Terekhov called “the most powerful attack” on Kharkiv since the start of the war.

Four people were killed and more than 50 wounded as homes and apartment blocks were hit overnight and guided bombs were dropped on the city on Saturday afternoon.

Ukraine is also stepping up its drone attacks on Russia, targeting military production and bases.

On Tuesday, one person was killed and four others wounded in a drone attack that destroyed a convenience store in the Russian region of Belgorod, according to Governor Vyacheslav Gladkov.

Nevertheless, the two sides carried out a second prisoner of war swap on Tuesday.

The deal should see the freeing of all captured soldiers under the age of 25, as well as those who are sick or severely wounded, though neither side has specified the number of soldiers involved.

But Zelensky has said it is “pointless” to hold further talks with the current Russian delegation – who he previously dismissed as “empty heads” – since they could not agree to a ceasefire.

As a condition for halting its invasion, Russia has demanded that Ukraine cede the territories Moscow says it has annexed and forswear joining NATO.

It has also rejected a proposed 30-day unconditional ceasefire sought by Kyiv and the European Union, arguing that this would allow Ukrainian forces to rearm with Western deliveries.

Ukraine is demanding a complete Russian withdrawal of from its territory and security guarantees from the West.


The US and China have agreed on a framework to resolve their trade disputes

Updated 11 June 2025
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The US and China have agreed on a framework to resolve their trade disputes

LONDON: Senior US and Chinese negotiators have agreed on a framework to move forward on trade talks after a series of disputes had threatened to derail them, Chinese state media said Wednesday.
The announcement followed two days of talks in the British capital that ended late Tuesday.
The disputes had shaken a fragile truce reached in Geneva last month, leading to a phone call last week between President Donald Trump and Chinese leader Xi Jinping to try to calm the waters.
Li Chenggang, a vice minister of commerce and China’s international trade representative, said the two sides had agreed in principle on a framework for implementing the consensus reached between the two leaders and at the talks on Geneva, the official Xinhua News Agency said.
Further details, including any plans for a potential next round of talks, were not immediately available.
Li and Wang Wentao, China’s commerce minister, were part of the delegation led by Vice Premier He Lifeng. They met with US Commerce Secretary Howard Lutnick, Treasury Secretary Scott Bessent and Trade Representative Jamieson Greer at Lancaster House, a 200-year-old mansion near Buckingham Palace.
Wendy Cutler, a former US trade negotiator, said the disputes had frittered away 30 of the 90 days the two sides have to try to resolve their disputes.
They had agreed in Geneva to a 90-day suspension of most of the 100 percent-plus tariffs they had imposed on each other in an escalating trade war that had sparked fears of recession.
“The US and China lost valuable time in restoring their Geneva agreements,” said Cutler, now vice president at the Asia Society Policy Institute. “Now, only sixty days remain to address issues of concern, including unfair trade practices, excess capacity, transshipment and fentanyl.”
Since the Geneva talks, the US and China have exchanged angry words over advanced semiconductors that power artificial intelligence, visas for Chinese students at American universities and rare earth minerals that are vital to carmakers and other industries.
China, the world’s biggest producer of rare earths, has signaled it may ease export restrictions it placed on the elements in April. The restrictions alarmed automakers around the world who rely on them. Beijing, in turn, wants the US to lift restrictions on Chinese access to the technology used to make advanced semiconductors.
Cutler said it would be unprecedented for the US to negotiate on its export controls, which she described as an irritant that China has been raising for nearly 20 years.
“By doing so, the US has opened a door for China to insist on adding export controls to future negotiating agendas,” she said.
Trump said earlier that he wants to “open up China,” the world’s dominant manufacturer, to US products.
“If we don’t open up China, maybe we won’t do anything,” Trump said at the White House. “But we want to open up China.”


Pakistan hikes defense budget 20% following conflict with India, but overall spending is cut

Updated 16 min ago
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Pakistan hikes defense budget 20% following conflict with India, but overall spending is cut

  • Finance minister says 14 percent of the proposed 17.57 trillion rupees ($62 billion) budget will go to the military
  • India in February increased its defense spending by 9.5 percent to a record high of $78.8 billion for 2025-2026

ISLAMABAD: Pakistan has hiked defense spending by 20 percent following last month’s deadly conflict with India.
The government of Prime Minister Shehbaz Sharif announced the increase as part of the budget for the fiscal year 2025-26, in which overall spending will be cut by 7 percent to 17.57 trillion rupees ($62 billion).

Finance Minister Muhammad Aurangzeb presented the budget to parliament on Tuesday evening, allocating 14 percent to the military.

It comes after Pakistan’s government announced Friday on social media that it was in discussions to acquire 40 new Chinese fighter jets and new air defense systems.

Pakistan and India were pushed to the brink of war earlier this year after a gun massacre of tourists in Indian-controlled Kashmir, marking the biggest breakdown in relations between them since 2019.

More than 70 people were killed in the four-day conflict between the nuclear-armed neighbors in May before a ceasefire was announced.
 

Aurangzeb said the government was allocating 2.55 trillion rupees ($9 billion) for defense compared with 2.12 trillion rupees in the previous budget.
India in February increased its defense spending by 9.5 percent to a record high of $78.8 billion for 2025-2026.

Sharif told the Cabinet: “All economic indicators are satisfactory. After defeating India in a conventional war, now we have to go beyond it in the economic field as well.”
Opposition members of the National Assembly verbally abused Aurangzeb, chanting slogans, throwing scrunched-up copies of the budget at him, whistling, and banging their desks as he gave his address.
The coming year’s defense allocation is considerably more than the government’s expenditure on higher education, agricultural development, and mitigating climate-related risks, to which Pakistan is especially prone.

Brink of default

Pakistan came to the brink of default in 2023, as a political crisis compounded an economic downturn and drove the nation’s debt burden to terminal levels, before it was saved by a $7 billion bailout from the International Monetary Fund.
It has since then enjoyed a degree of recovery, with inflation easing and foreign exchange reserves increasing.
“We have moved in the right direction,” Aurangzeb said at a briefing ahead of the budget announcement in parliament.
“Any transformation takes two to three years and we have done a good job in terms of where we wanted to take things.”
The budget will be voted on by parliament later this month, but the government’s safe majority means only minor changes are expected.
An economic survey released on Monday for the outgoing fiscal year which ends on June 30, showed that the country missed almost all the targets set at the beginning of the year, with GDP expected to grow by 2.7 percent — falling short of the initial 3.6 percent target set in the last budget.
The government has set an ambitious target of 4.2 percent GDP growth for the next fiscal year.
The budget set aside 8 trillion rupees ($28.4 billion) to service its huge amount of debt.
A World Bank report said last week that nearly 45 percent of Pakistan’s 240 million population is living below the poverty line, while the country’s literacy rate stands at 61 percent.
It is the government’s second budget since coming to power last year, in an election which saw the wildly popular leader Imran Khan jailed for charges he says were politically motivated.

 


Los Angeles mayor imposes curfew on downtown following increased nighttime violence

Updated 11 June 2025
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Los Angeles mayor imposes curfew on downtown following increased nighttime violence

  • The curfew is a necessary measure to protect lives and safeguard property following several consecutive days of growing unrest throughout the city

LOS ANGELES: Mayor Karen Bass issued a curfew for downtown Los Angeles on Tuesday “to stop the vandalism, to stop the looting.”
She said in a news conference that she had declared a local emergency and that the curfew will run from 8 p.m. Tuesday until 6 a.m. Wednesday.
“We reached a tipping point” after 23 businesses were looted, Bass said.
The curfew will be in place in a 1 square mile (2.59 square kilometer) section of downtown that includes the area where protests have occurred since Friday. The city of Los Angeles encompasses roughly 500 square miles (2,295 square kilometers).
The curfew doesn’t apply to residents who live in the designated area, people who are homeless, credentialed media or public safety and emergency officials, according to Los Angeles Police Chief Jim McDonnell.
McDonnell said “unlawful and dangerous behavior” had been escalating since Saturday.
“The curfew is a necessary measure to protect lives and safeguard property following several consecutive days of growing unrest throughout the city,” McDonnell said.
Earlier Tuesday, National Guard troops began protecting immigration agents as they made arrests in Los Angeles on Tuesday, an expansion of their duties that had been limited to protecting federal property. Photos posted Tuesday by US Immigration and Customs Enforcement show National Guard troops standing guard around officers as they made arrests.
ICE said in a statement that the troops were providing security at federal facilities and protecting federal officers “who are out on daily enforcement operations.” The change moves troops closer to engaging in law enforcement actions like deportations as President Donald Trump has promised as part of the administration’s immigration crackdown.
The agency said Guard members are also providing support with transportation. The Guard has the authority to temporarily detain people who attack officers but any arrests ultimately would be made by law enforcement.
National Guard troops and Marines deployed to LA
California Gov. Gavin Newsom had asked a federal court to block the Trump administration from using the National Guard and Marines to assist with immigration raids in Los Angeles, saying it would only heighten tensions and promote civil unrest.
Newsom filed the emergency request after Trump ordered the deployment to LA of roughly 4,000 National Guard troops and 700 Marines following protests of the president’s stepped-up enforcement of immigration laws.
The federal government said Newsom was seeking an unprecedented and dangerous order that would interfere with its ability to carry out enforcement operations. A judge set a hearing for Thursday.
The Marines and another 2,000 National Guard troops were sent to LA on Monday, adding to a military presence that local officials and Newsom do not want and that the police chief says makes it harder to handle the protests safely.
Marine Corps Gen. Eric Smith said Tuesday that the Marines had not yet been called to respond to the protests and were there only to protect federal officials and property. The Marines were trained for crowd control but have no arrest authority, Smith told a budget hearing on Capitol Hill.
Marines were not seen on the streets yet, while National guard troops so far have had limited engagement with protesters.
Trump says he’s open to using Insurrection Act
Trump left open the possibility of invoking the Insurrection Act, which authorizes the president to deploy military forces inside the US to suppress rebellion or domestic violence or to enforce the law in certain situations. It’s one of the most extreme emergency powers available to a US president.
“If there’s an insurrection, I would certainly invoke it. We’ll see,” he said from the Oval Office.
Later the president called protesters “animals” and “a foreign enemy” in a speech at Fort Bragg ostensibly to recognize the 250th anniversary of the US Army.
Trump has described Los Angeles in dire terms that Mayor Karen Bass and Newsom say are nowhere close to the truth.
The protests began Friday after federal immigration raids arrested dozens of workers in Los Angeles. Protesters blocked a major freeway and set cars on fire over the weekend, and police responded with tear gas, rubber bullets and flash-bang grenades.
The demonstrations have been mostly concentrated downtown in the city of 4 million and have been far less raucous since the weekend. Thousands of people have peacefully rallied outside City Hall and hundreds more protested outside a federal complex that includes a detention center where some immigrants are being held following workplace raids.
Several businesses were broken into Monday, though authorities didn’t say if the looting was tied to the protests. Nejdeh Avedian, general manager at St. Vincent Jewelry Center in the Los Angeles Jewelry District said the protesters had already left, and “these guys were just opportunists,” though St. Vincent’s had armed guards and was left alone.
Homeland Security Assistant Secretary Tricia McLaughlin said in a statement Tuesday that protesters have hurled rocks and Molotov cocktails at law enforcement, set vehicles on fire, defaced buildings and public property and set fire to American flags.
The Los Angeles Police Department said there have been more than 100 arrests. The vast majority were for failing to disperse, while a few others were for assault with a deadly weapon, looting, vandalism and attempted murder for tossing a Molotov cocktail. Seven police officers were reportedly injured, and at least two were taken to a hospital and released.
On Tuesday, a few dozen protesters gathered peacefully in front of the federal complex, which was quickly declared an unlawful assembly. Police issued a dispersal order and corralled the protesters, telling members of the media to stay out to avoid getting hurt. Officers with zip ties then started making arrests.
Obscene slogans directed at Trump and federal law enforcement remained scrawled across several buildings. At the Walt Disney Concert Hall, workers were busy washing away graffiti Tuesday.
In nearby Santa Ana, armored Guard vehicles blocked a road leading to federal immigration and government offices.
Defense Secretary Pete Hegseth suggested Tuesday that the use of troops inside the US will continue to expand.
“I think we’re entering another phase, especially under President Trump with his focus on the homeland, where the National Guard and Reserves become a critical component of how we secure that homeland,” he said on Capitol Hill.
Los Angeles officials say police don’t need help

The mayor and the governor say Trump is putting public safety at risk by adding military personnel even though police say they don’t need the help.
Los Angeles Police Chief Jim McDonnell said he was confident in the police department’s ability to handle the demonstrations and that the Marines’ arrival without coordinating with police would present a “significant logistical and operational challenge.”
Demonstrations have spread to other cities nationwide, including San Francisco, as well as Dallas and Austin, Texas, Chicago and New York City, where a thousand people rallied and multiple arrests were made.
LA response takes stage on Capitol Hill
The Pentagon said deploying the National Guard and Marines costs $134 million.
Meanwhile, Democratic members of California’s congressional delegation on Tuesday accused the president of creating a “manufactured crisis.”
On Monday, California Attorney General Rob Bonta filed a lawsuit seeking to halt the deployment.
Trump said the city would have been “completely obliterated” if he had not deployed the Guard.
The deployment appeared to be the first time in decades that a state’s National Guard was activated without a request from its governor, a significant escalation against those who have sought to hinder the administration’s mass deportation efforts.