PARIS: The vaccine made by Pfizer and BioNTech appears to retain its effectiveness against coronavirus mutations in worrying new variants that have emerged recently in Britain and South Africa, the firms said Thursday.
Several new variants — each with a cluster of genetic mutations — have sparked fears over an increase in infectiousness as well as suggestions that the virus could begin to elude immune response, whether from prior infection or a vaccine.
Pfizer/BioNTech, which had previously said it was unlikely that the strain originally found in Britain could escape vaccine protection, said Thursday that early tests suggest their immunization would be similarly protective against the variant in South Africa.
In a statement, the two companies said these preliminary findings “do not indicate the need for a new vaccine to address the emerging variants.”
They said they are “prepared to respond” if a new strain is shown to be able to evade the immunity of the vaccine, adding that they can produce updates to their jab if needed.
The statement comes after US biotech firm Moderna this week announced that lab studies suggest its vaccine should protect against the variants first found in the United Kingdom and South Africa.
The latest Pfizer/BioNTech research, which has not yet been peer reviewed, was carried out by researchers from Pfizer and the University of Texas.
The authors compared the antibodies of 20 people who had received two doses of the Pfizer/BioNTech vaccine during clinical trials with lab-engineered sets of mutations present in the variants that emerged in Britain and South Africa.
The new variants — along with another linked to Brazil — have mutations to the virus’ spike protein, which enables the virus to latch onto human cells and therefore plays a key role in driving infections.
One mutation in particular — known as E484K and found in the South Africa and Brazil strains but not the one in Britain — has experts particularly worried about immunity “escape.”
The study found that the antibodies were able to neutralize all the sets of mutations tested.
It noted that the effect was “slightly lower” against three mutations in the variant found in South Africa, including E484K.
But the firms said that it was “unlikely to lead to a significant reduction in the effectiveness of the vaccine.”
They said they were looking to test against the full set of mutations in the spike protein of the variant that emerged in South Africa.
A study released last week by researchers in South Africa, which has also not yet been peer reviewed, tested the variant found there against blood plasma from recovered Covid-19 patients.
They found that it was resistant to neutralising antibodies built up from prior infection, but said more research was needed into the effectiveness of other parts of the immune response.
Daily global deaths from Covid-19 topped 18,000 for the first time Wednesday, with vaccines seen as the only real chance of returning to some form of normality.
The German firm BioNTech had already said the messenger RNA technology means it could update the vaccine against new variants within weeks.
Pfizer/BioNTech say vaccine effective against UK, South Africa virus mutations
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Pfizer/BioNTech say vaccine effective against UK, South Africa virus mutations
- Pfizer/BioNTech say preliminary findings “do not indicate the need for a new vaccine to address the emerging variants”
- Companies “prepared to respond” if new strain is shown to be able to evade the immunity of the vaccine
Violence against children hit ‘unprecedented levels in 2024’
- The UN kept Israeli forces on its blacklist of countries that violate children’s rights for a second year, citing 7,188 verified grave violations by its military, including the killing of 1,259 Palestinian children and injury to 941 others in Gaza
- UN chief cites warfare strategies that included deployment of destructive and explosive weapons
NEW YORK: Violence against children caught in multiple and escalating conflicts reached “unprecedented levels” last year, with the highest number of violations in Gaza and the West Bank, Congo, Somalia, Nigeria and Haiti, according to a UN report.
Secretary-General Antonio Guterres’ annual report on Children in Armed Conflict detailed “a staggering 25 percent surge in grave violations” against children under the age of 18 from 2023, when the number of such violations rose by 21 percent.
In 2024, the UN chief said children “bore the brunt of relentless hostilities and indiscriminate attacks, and were affected by the disregard for ceasefires and peace agreements and by deepening humanitarian crises.”
FASTFACT
UN Secretary-General Antonio Guterres said he is ‘appalled by the intensity of grave violations against children in the occupied Palestinian territories and Israel,’ and ‘deeply alarmed’by the increase in violations, especially the high number of children killed by Israeli forces.
He cited warfare strategies that included attacks on children, the deployment of increasingly destructive and explosive weapons in populated areas, and “the systematic exploitation of children for combat.”
Guterres said the UN verified 41,370 grave violations against children — 36,221 committed in 2024 and 5,149 committed earlier but verified last year.
The violations include killing, maiming, recruiting and abducting children, sexual violence against them, attacking schools and hospitals, and denying youngsters access to humanitarian aid.
The UN kept Israeli forces on its blacklist of countries that violate children’s rights for a second year, citing 7,188 verified grave violations by its military, including the killing of 1,259 Palestinian children and injury to 941 others in Gaza.
The Gaza Health Ministry has reported much higher figures, but the UN has strict criteria and said its process of verification is ongoing.
Guterres said he is “appalled by the intensity of grave violations against children in the occupied Palestinian territories and Israel,” and “deeply alarmed” by the increase in violations, especially the high number of children killed by Israeli forces.
He reiterated his calls on Israel to abide by international law requiring special protections for children, protection for schools and hospitals, and compliance with the requirement that attacks distinguish between combatants and civilians and avoid excessive harm to civilians.
The UN also kept Hamas and Palestinian Islamic Jihad on the blacklist.
Israel’s UN Mission did not immediately respond to a request for comment.
In Congo, the UN reported 4,043 verified grave violations against 3,418 children last year.
In Somalia, it reported 2,568 violations against 1,992 children.
In Nigeria, 2,436 grave violations were reported against 1,037 children. And in Haiti, the UN reported 2,269 verified grave violations against 1,373 children.
In the ongoing war following Russia’s February 2022 invasion of Ukraine, the UN kept the Russian armed forces and affiliated armed groups on its blacklist for a third year. The secretary-general expressed deep concern at “the sharp increase in grave violations against children in Ukraine” — 1,914 against 673 children.
He expressed alarm at the violations by Russian forces and their affiliates, singling out their verified killing of 94 Ukrainian children, injury to 577 others, and 559 attacks on schools and 303 on hospitals.
In Haiti, the UN put a gang, the Viv Ansanm coalition, on the blacklist for the first time.
Gangs have grown in power since the assassination of President Jovenel Moise in July 2021.
They are estimated to control 85 percent of the capital and have moved into surrounding areas.
In May, the US designated the powerful coalition representing more than a dozen gangs, whose name means “Living Together,” as a foreign terrorist organization.
Secretary-General Guterres expressed deep “alarm” at the surge in violations, especially incidents of gang recruitment and use, sexual violence, abduction, and denial of humanitarian aid.
The report said sexual violence jumped by 35 percent in 2024, including a dramatic increase in the number of gang rapes, but stressed that the numbers are vastly underreported.
“Girls were abducted for the purpose of recruitment and use, and for sexual slavery,” the UN chief said. In Haiti, the UN reported sexual violence against 566 children, 523 of them girls, and attributed 411 to the Viv Ansanm gang.
In Congo, the UN reported 358 acts of sexual violence against girls — 311 by armed groups and 47 by Congo’s armed forces. And in Somalia, 267 children were victims of sexual violence, 120 of them carried out by Al-Shabab extremists.
According to the report, violations affected 22,495 children in 2024, with armed groups responsible for almost 50 percent and government forces the main perpetrator of the killing and maiming of children, school attacks, and denial of humanitarian access.
The report noted a sharp rise in the number of children subjected to multiple violations — from 2,684 in 2023 to 3,137 in 2024.
“The cries of 22,495 innocent children who should be learning to read or play ball — but instead have been forced to learn how to survive gunfire and bombings — should keep all of us awake at night,” said Virginia Gamba, the UN special representative for children and armed conflict.
“We are at the point of no return,” she said, calling on the international community to protect children and the parties in conflict “to immediately end the war on children.”
Italy grapples with mass exodus and foreign influx amid economic fears
- Ukrainians made up the biggest national group among those who arrived in 2023-2024, Istat said, followed by Albanians, Bangladeshis, Moroccans, Romanians, Egyptians, Pakistanis, Argentines, and Tunisians
ROME: The number of Italians leaving their country and foreigners moving in has soared to the highest in a decade, official data showed on Friday, fueling national concerns about brain drain, economic decline, and immigration.
Italy has a right-wing government elected in 2022 on a mandate to curb migrant arrivals, but also has a shrinking population and growing labor shortages, highlighting the need to attract foreign workers.
Meanwhile, the country’s stagnant economy and low wages — salaries are below 1990 levels in inflation-adjusted terms — have been blamed for pushing many Italians to seek better fortunes abroad.
FASTFACT
Ukrainians made up the biggest national group among those who arrived in 2023-2024, followed by Albanians, Bangladeshis, Moroccans, Romanians, Egyptians, Pakistanis, Argentines, and Tunisians.
Last year, 382,071 foreigners moved to Italy, up from 378,372 in 2023 and the highest since 2014, the statistics agency Istat said.
In the same period, 155,732 Italians emigrated, up from 114,057 in 2023 and also the highest since 2014. The immigration figure beat the previous high for the last decade of 301,000 in 2017, and was well above that period’s low of 191,766 from 2020 — the height of the COVID pandemic.
The figure of almost 270,000 nationals emigrating in the two-year period from 2023 to 2024 was up around 40 percent compared to the previous two years.
The two-year immigration figure for that period, around 760,000, was up 31 percent from 2021-2022.
The figures are derived from town registry offices, so are unlikely to reflect undocumented migration.
Ukrainians made up the biggest national group among those who arrived in 2023-2024, Istat said, followed by Albanians, Bangladeshis, Moroccans, Romanians, Egyptians, Pakistanis, Argentines, and Tunisians.
As for the high number of emigrants, “it is more than plausible” that a significant number were “former immigrants” who moved abroad after acquiring Italian citizenship, Istat said.
The agency also said Italy’s poorer south was continuing to depopulate, noting that almost 1 percent of residents in Calabria, the region with the lowest per capita income, moved to central or northern areas during 2023-2024.
Russia might try to take Ukrainian city of Sumy, Putin says
- Ukraine said Putin’s comments showed “disdain” for the peace process
- “We have no objective to take Sumy, but in principle I do not rule it out... They pose a constant threat to us, constantly shelling the border areas,” Putin said
SAINT PETERSBURG: Russian President Vladimir Putin said Friday he did not “rule out” his forces attempting to seize the northeastern Ukrainian city of Sumy, casting fresh doubt over the prospect of peace talks between Moscow and Kyiv.
Ukraine said Putin’s comments showed “disdain” for the peace process.
Diplomatic efforts to end the three-year conflict have stalled in recent weeks and Kyiv has accused Moscow of deliberately sabotaging a peace deal to prolong its full-scale offensive on the country.
Russia currently occupies around a fifth of Ukraine and has claimed four Ukrainian regions as its own since launching its assault in 2022, in addition to Crimea, which it captured in 2014.
The Sumy region is not one of the regions Moscow has formally annexed, although Russian forces have recently made inroads there for the first time in three years.
At Russia’s flagship economic forum in Saint Petersburg, Putin suggested Moscow could take Sumy as part of the creation of a “buffer zone” along the border and repeated his denial of Ukrainian statehood.
“We have no objective to take Sumy, but in principle I do not rule it out... They pose a constant threat to us, constantly shelling the border areas,” Putin said.
“I consider Russians and Ukrainians to be one people. In that sense, all of Ukraine is ours,” he told attendees, when asked why his army was entering areas Moscow did not claim as its own.
“There is a saying: wherever a Russian soldier sets foot, that is ours.”
Ukrainian Foreign Minister Andriy Sybiga described Putin’s comments as “deranged” and called for Kyiv’s allies to slap “devastating sanctions” on Russia.
“The only way to force Russia into peace is to deprive it of its sense of impunity,” he wrote in a post on X.
Putin’s widening territorial ambitions are likely to roil Ukrainian President Volodymyr Zelensky,
who has accused Moscow of not wanting to end the fighting.
The two sides held rounds of direct talks in Istanbul in May and in June, but Kyiv accused Moscow of sending “dummy” negotiators with no real power to enact a peace deal.
Putin has declined to take part in the peace talks in person and on Thursday said he would only meet Zelensky during a “final phase” of negotiations on ending the three-year conflict.
He has also insisted Ukraine give up territory it already controls for peace.
Kyiv says it cannot and will not accept Russian occupation of any part of its land.
In his address Friday, Putin denied he was calling for Ukraine to “capitulate.”
“We are not seeking Ukraine’s surrender. We insist on recognition of the realities that have developed on the ground,” the Russian leader said.
Putin repeated that Moscow was “advancing on all fronts” and that his troops had penetrated up to 12 kilometers (seven miles) into the Sumy region.
He also accused Kyiv of “stupidity” by launching an incursion into Russia’s Kursk region last August.
“They are creating problems for themselves,” he said.
Russia has for months been rejecting calls for an unconditional ceasefire, launching deadly attacks on its neighbor.
Europeans’ meeting with top Iranian diplomat yields hope of more talks, no obvious breakthrough
- It was the first face-to-face meeting between Western and Iranian officials since the start of the conflict
- “The good result today is that we leave the room with the impression that the Iranian side is fundamentally ready to continue talking,” Wadephul said
GENEVA: A meeting between Iran’s foreign minister and top European diplomats on Friday yielded hopes of further talks but no indication of any immediate concrete breakthrough, a week after the crisis centered on the Iranian nuclear program erupted into war between Israel and Tehran.
Foreign ministers from Britain, France and Germany, as well as the European Union’s foreign policy chief, emerged from talks at a Geneva hotel about 3 1/2 hours after Iran’s Abbas Araghchi arrived for the meeting.
It was the first face-to-face meeting between Western and Iranian officials since the start of the conflict.
“The good result today is that we leave the room with the impression that the Iranian side is fundamentally ready to continue talking about all important issues,” German Foreign Minister Johann Wadephul said. He said the two sides had held “very serious talks.”
British Foreign Secretary David Lammy said: “We are keen to continue ongoing discussions and negotiations with Iran, and we urge Iran to continue their talks with the United States.” He added that “we were clear: Iran cannot have a nuclear weapon.”
“Military operations can slow Iran’s nuclear program but in no way can they eliminate it, said French Foreign Minister Jean-Noël Barrot. “We know well — after having seen what happened in Afghanistan, in Iraq, in Libya — how illusory and dangerous it is to want to impose regime change from outside.”
Barrot also said that European nations ”invited the Iranian minister to envisage negotiations with all parties including the United States, and without waiting for the end of the strikes.”
The French Foreign Minister explained that in discussions with Iran, Foreign Minister Araghchi agreed “to put all the issues on the table including some that weren’t there before” and “showed his disposition to continuing the conversation — that we started today — and for the Europeans to help facilitate, including with the United States.”
EU foreign policy chief Kaja Kallas said ”we agreed that we will discuss nuclear but also broader issues that we have, and keep the discussions open.”
Iran’s Foreign Minister Abbas Araghchi also addressed reporters outside the meeting venue after the talks ended. He expressed support for “a continuation of discussions with the E3 and the EU and expressed his readiness to meet again in the near future.” He also denounced Israel’s attacks against nuclear facilities in Iran and expressed “grave concern” on what he called “non-condemnation” by European nations.
US considering how to proceed
Lammy traveled to Geneva after meeting in Washington with US Secretary of State Marco Rubio and President Donald Trump’s Mideast envoy, Steve Witkoff.
Trump has been weighing whether to attack Iran by striking its well-defended Fordo uranium enrichment facility, which is buried under a mountain and widely considered to be out of reach of all but America’s “bunker-buster” bombs. He said Wednesday that he’ll decide within two weeks whether the US military will get directly involved in the war given the “substantial chance” for renewed negotiations over Tehran’s nuclear program.
Israel says it launched its airstrike campaign to stop Iran from getting closer to being able to build a nuclear weapon. Iran and the United States had been negotiating over the possibility of a new diplomatic deal over Tehran’s program, though Trump has said Israel’s campaign came after a 60-day window he set for the talks.
French Foreign Minister Jean-Noël Barrot said that “we wanted to open a discussion with the Iranian foreign minister because we believe that there is no definitive solution by military means to the Iranian nuclear problem — military operations may delay it but they can’t eliminate it.”
Singer Chris Brown pleads not guilty
- Brown was originally charged with a single count of grievous bodily harm after his arrest in May, but prosecutors subsequently brought an indictment adding two counts: assault causing actual bodily harm and having an offensive weapon, a bottle
LONDON: Grammy-winning singer Chris Brown pleaded not guilty Friday to a charge related to the serious beating of a music producer with a bottle in a London nightclub in 2023.
Brown, 36, wearing a blue suit, white shirt and black-rimmed glasses, was arraigned in London’s Southwark Crown Court on one count of attempting to unlawfully and maliciously cause grievous bodily harm with intent.
Brown’s friend and fellow musician Omololu Akinlolu, 39, who performs under the name “Hoody Baby,” pleaded not guilty to the same charge.
Prosecutors previously said Brown and Akinlolu assaulted producer Abe Diaw at a bar in the Tape nightclub in the swanky Mayfair neighborhood in February 2023. Brown allegedly launched an unprovoked attack on Diaw and hit him several times with a bottle and then punched and kicked him.
The attack was caught on surveillance camera in front of a club full of people, prosecutors said.
Brown was originally charged with a single count of grievous bodily harm after his arrest in May, but prosecutors subsequently brought an indictment adding two counts: assault causing actual bodily harm and having an offensive weapon, a bottle.
When a court clerk asked Brown how he pleaded to the grievous bodily harm count, he replied: “Not guilty ma’am.”
Brown did not enter pleas on the additional counts and was ordered to return to court July 11 to face those charges after wrapping up the European leg of his world tour. His trial was scheduled for Oct. 26, 2026.
The singer of “Go Crazy,” “Run It,” and “Kiss Kiss” was released last month on a 5 million-pound ($6.75 million) bail, which allowed him to start his “Breezy Bowl XX” tour earlier this month.
Following his release after almost a week in jail, Brown posted on Instagram: “FROM THE CAGE TO THE STAGE!!! BREEZYBOWL.”
Brown, who quickly rose to stardom as a teen in 2005, won his first Grammy for best R&B album in 2011 for “F.A.M.E.” and then earned his second in the same category for “11:11 (Deluxe)” earlier this year.
