New research suggests that Pfizer’s COVID-19 vaccine can protect against a mutation found in two contagious variants of the coronavirus that erupted in Britain and South Africa.
Those variants are causing global concern. They both share a common mutation called N501Y, a slight alteration on one spot of the spike protein that coats the virus. That change is believed to be the reason they can spread so easily.
Most of the vaccines being rolled out around the world train the body to recognize that spike protein and fight it. Pfizer teamed with researchers from the University of Texas Medical Branch in Galveston for laboratory tests to see if the mutation affected its vaccine’s ability to do so.
They used blood samples from 20 people who received the vaccine, made by Pfizer and its German partner BioNTech, during a large study of the shots. Antibodies from those vaccine recipients successfully fended off the virus in lab dishes, according to the study posted late Thursday on an online site for researchers.
The study is preliminary and has not yet been reviewed by experts, a key step for medical research.
But “it was a very reassuring finding that at least this mutation, which was one of the ones people are most concerned about, does not seem to be a problem” for the vaccine, said Pfizer chief scientific officer Dr. Philip Dormitzer.
Viruses constantly undergo minor changes as they spread from person to person. Scientists have used these slight modifications to track how the coronavirus has moved around the globe since it was first detected in China about a year ago.
British scientists have said the variant found in the UK – which has become the dominant type in parts of England — still seemed to be susceptible to vaccines. That mutant has now been found in the US and numerous other countries.
But the variant first discovered in South Africa has an additional mutation that has scientists on edge, one named E484K.
The Pfizer study found that the vaccine appeared to work against 15 additional possible virus mutations, but E484K wasn’t among those tested. Dormitzer said it is next on the list.
Dr. Anthony Fauci, the top US infectious disease expert, recently said vaccines are designed to recognize multiple parts of the spike protein, making it unlikely a single mutation could be enough to block them. But scientists around the world are conducting research with different vaccines to find out.
Dormitzer said if the virus eventually mutates enough that the vaccine needs adjusting – much like flu shots are adjusted most years – that tweaking the recipe wouldn’t be difficult for his company’s shot and similar ones. The vaccine is made with a piece of the virus genetic code, simple to switch, although it’s not clear what kind of additional testing regulators would require to make such a change.
Dormitzer said this was only the beginning “of ongoing monitoring of virus changes to see if any of them might impact on vaccine coverage.”
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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.
Pfizer study suggests vaccine works against virus variant
https://arab.news/zx9p2
Pfizer study suggests vaccine works against virus variant
- The study is preliminary and has not yet been reviewed by experts, a key step for medical research
- Viruses constantly undergo minor changes as they spread from person to person
Defense chief Hegseth shared war plans in second Signal chat, NYT reports
- The Trump administration has aggressively pursued leaks, an effort that has been enthusiastically embraced by Hegseth at the Pentagon
WASHINGTON: Defense Secretary Pete Hegseth shared details of a March attack on Yemen’s Iran-aligned Houthis in a message group that included his wife, brother and personal lawyer, the New York Times reported on Sunday, raising more questions about his use of an unclassified messaging system to share highly-sensitive security details.
Hegseth allegedly shared the same details of the attack that were revealed last month by The Atlantic magazine after its editor-in-chief, Jeffrey Goldberg, was included in a separate chat on the Signal app by mistake, in an embarrassing incident involving all of President Donald Trump’s most senior national security officials.
The Times, citing four sources familiar with the message group, said that second chat included details of the schedule of the air strikes.
Hegseth’s wife Jennifer, a former Fox News producer, has also reportedly attended sensitive meetings with foreign military counterparts, the Wall Street Journal has separately reported.
Revelations of another use of Signal for classified information come as one of Hegseth’s leading advisers, Dan Caldwell, was escorted from the Pentagon last week after being identified during an investigation into leaks at the Department of Defense, a US official told Reuters.
Following Caldwell’s departure, less senior officials Darin Selnick, who recently became Hegseth’s deputy chief of staff, and Colin Carroll, who was chief of staff to Deputy Defense Secretary Steve Feinberg, were put on administrative leave, officials said.
The Trump administration has aggressively pursued leaks, an effort that has been enthusiastically embraced by Hegseth at the Pentagon.
The Pentagon was not immediately available for comment.
Trump says he hopes Russia, Ukraine to strike ‘deal this week’
WASHINGTON: US President Donald Trump said Sunday that he hoped for a Russia-Ukraine peace deal “this week,” promising “big business with the United States” for both combatants if a truce is signed.
“Hopefully Russia and Ukraine will make a deal this week,” Trump posted to his Truth Social network, without giving details of any progress in peace talks Washington has sought to push forward since he took over from Joe Biden in January.
Congo suspends Kabila’s political party
- Joseph Kabila, who was president for 18 years up to 2019, remains head of his People’s Party for Reconstruction and Democracy, the Interior Ministry said
KINSHASA: The Democratic Republic of Congo government said it suspended the political party of former President Joseph Kabila days after security services raided his properties.
“This decision follows the overt activism” of Kabila, who was president for 18 years up to 2019 and remains head of his People’s Party for Reconstruction and Democracy, PPRD, the Interior Ministry said in a statement.
PPRD activities “are suspended across all the national territory,” the statement said.
There was no immediate reaction from the party.
Current leader President Felix Tshisekedi has accused Kabila of preparing “an insurrection” and backing an alliance that includes the M23 armed group that is fighting government forces in eastern DR Congo.
According to a spokesman for his family, Kabila, 53, left the country before the last presidential election in 2023.
But in early April, in a message relayed by his staff, he said he would return on an unspecified date because the country was “in peril.”
There are unconfirmed suggestions that he will arrive, or is already in, the eastern city of Goma.
The family spokesman said on Thursday that security services mounted raids on Kabila’s main property, a farm east of Kinshasa, and on a compound belonging to the family in the capital.
The Interior Ministry statement accused Kabila’s party of keeping “a guilty, or even complicit, silence” over “the Rwandan war of aggression.”
Kinshasa, UN experts, and several international powers have said M23 is backed by Rwanda, which denies the charge.
The armed group is at the center of a new surge in conflict in eastern DR Congo, having taken the key cities of Goma and Bukavu.
The DR Congo ministry statement said Kabila has maintained an “ambiguous attitude” on the M23 rebellion, which he “has never condemned.”
It criticized Kabila’s “deliberate choice” to enter the country through the city of Goma, under the “control of the enemy.”
A separate statement from the country’s Justice Ministry said the chief prosecutor had been asked to start legal action against Kabila for “his direction participation” in M23.
Exec linked to Bangkok building collapse arrested
BANGKOK: Thai authorities said they have arrested a Chinese executive at a company that was building a Bangkok skyscraper which collapsed in a major earthquake, leaving dozens dead.
The 30-story tower was reduced to an immense pile of rubble when a 7.7-magnitude quake struck neighboring Myanmar last month, killing 47 people at the construction site and leaving another 47 missing.
Justice Minister Tawee Sodsong told a news conference Saturday that a Thai court had issued arrest warrants for four individuals, including three Thai nationals, at China Railway No.10 for breaching the Foreign Business Act.
The Department of Special Investigation, which is under the justice ministry, said in a statement Saturday that one of the four had been arrested — a Chinese “company representative” who they named as Zhang.
China Railway No.10 was part of a joint venture with an Italian-Thai firm to build the State Audit Office tower before its collapse.
Zhang is listed as a 49-percent shareholder in the firm, while the three Thai citizens have a 51-percent stake in the company.
But Tawee told journalists that “we have evidence ... that the three Thais were holding shares for other foreign independents.”
The Foreign Business Act says that foreigners may hold no more than 49 percent of shares in a company.
Separately, Tawee said several investigations related to the collapse were ongoing, including over the possibility of bid rigging and the use of fake signatures of engineers in construction supervisor contracts.
Earlier this month Thai safety officials said testing of steel rebars — struts used to reinforce concrete — from the site has found that some of the metal used was substandard.
The skyscraper was the only major building in the capital to fall in the catastrophic March 28 earthquake that has killed more than 3,700 people in Thailand and neighboring Myanmar.
Russia and Ukraine accuse each other of breaching Easter truce
- Ukraine’s forces reported 2,935 violations of Russia’s own Easter ceasefire vow, Zelensky said
- The 30-hour truce had been meant to start Saturday to mark the religious holiday
KRAMATORSK: Russia and Ukraine on Sunday accused each other of violating an Easter truce announced by Russian President Vladimir Putin.
The 30-hour truce had been meant to start Saturday to mark the religious holiday, but Ukraine’s President Volodymyr Zelensky accused Russia of keeping up its attacks on the front line.
Ukraine’s forces reported 2,935 violations of Russia’s own Easter ceasefire vow, Zelensky said early on Monday.
“The nature of Ukrainian actions will continue to be mirrored: we will respond to silence with silence, our strikes will be to protect against Russian strikes,” he said in a post on the Telegram messaging app.
Zelensky also renewed a proposal for a 30-day truce.
Moscow said it had “repelled” assaults by Ukraine and accused Kyiv of launching hundreds of drones and shells, causing civilian casualties.
“Despite the announcement of the Easter truce, Ukrainian units at night made attempts to attack” Russia’s positions in the Donetsk region, its defense ministry added.
Russian troops had “strictly observed the ceasefire,” the defense ministry insisted.
Rescue services in the eastern town of Kostyantynivka said they had recovered the bodies of a man and a woman from the ruins of building hit the previous day by Russian shelling.
The Russian-appointed mayor of Gorlovka in occupied Donetsk, Ivan Prikhodko, said two civilians had been wounded there, without giving details.
Russia launched a full-scale invasion of Ukraine in February 2022 and now occupies around 20 percent of the country.
Putin’s order to halt all combat over the Easter weekend came after months of efforts by US President Donald Trump to get the war rivals to agree to a ceasefire.
But on Friday, Trump threatened to withdraw from talks if no progress was made.
Ukrainian soldiers told AFP that they had noticed a lull in fighting.
A drone unit commander said that Russia’s activity had “significantly decreased both in Zaporizhzhia and Kharkiv regions,” combat zones in the south and northeast where the unit is active.
“Several assaults were recorded, but those were solitary incidents involving small groups,” the commander told AFP, speaking on condition of anonymity.
“Fewer guys (soldiers) will die today.”
Russian “artillery is not working. it is quiet compared to a regular day,” Sergiy, a junior lieutenant fighting in the Sumy border region, wrote to AFP in a message.
Ukrainian troops “are on the defensive,” he added. “If the enemy doesn’t move forward, they don’t shoot.”
AFP journalists monitoring in eastern Ukraine heard fewer explosions than usual and saw no smoke on the horizon.
Putin announced a truce from 6:00 p.m. (1500 GMT) Saturday to midnight Sunday Moscow time (2100 GMT), saying it was motivated by “humanitarian reasons.”
Zelensky responded that Ukraine was ready to follow suit and proposed extending the truce for 30 days to “give peace a chance.”
But he said Sunday that Russia “has not yet responded to this.”
Kremlin spokesman Dmitry Peskov said that Putin had given no order to extend the truce.
In Kyiv, as Easter Sunday bells rang out, people doubted Russia’s good faith.
“They’ve already broken their promise,” said 38-year-old Olga Grachova, who works in marketing. “Unfortunately, we cannot trust Russia today.”
Natalia, a 41-year-old medic, said of Zelensky’s 30-day proposal: “Everything we offer, unfortunately, remains only our offers. Nobody responds to them.”
People in Moscow welcomed an Easter truce and hoped for more progress toward an end to the war.
“We dreamt of course that peace would come by Easter. Let it come soon,” said Svetlana, a 34-year-old housewife.
“I think that this awful thing will end at some point, but not soon,” said Irina Volkova, a 73-year-old pensioner.
“All is not going well for us in Ukraine,” she added. “People are dying, our guys are dying.”
Moscow said this weekend that it had now recovered 99.5 percent of its Kursk region, which Ukrainian troops occupied in a surprise offensive in August.
